Vaginal Human Microbiome Project
The Vaginal Human Microbiome Project at VCU is funded by the NIH Roadmap Human Microbiome Project and has the goal of elucidating the roles of the women's urogenital conditions, physiological states, environmental factors and host genetic components to the structure and composition of the vaginal microbiome. Thousands of visitors to outpatient clinics and hundreds of twin pairs have enrolled and contributed tens of thousands of samples and phenotype data to the study. The study repository includes samples from three vaginal sites (mid-vagina, cervix and introitus), the buccal mucosa and the perianal region.
What changes in the microbiome are associated with common non-infectious pathological states of the host? What changes in the vaginal microbiome are associated with relevant infectious diseases and conditions?
Principal Investigators: Gregory A. Buck, PhD; Kimberly K. Jefferson, PhD Jerome F. Strauss, III, MD, PhD; Lindon J. Eaves, PhD
Multi'Omic Microbiome Study-Pregnancy Initiative
What is the impact of pregnancy on the maternal microbiome? How does the microbiome effect maternal host response? How do the maternal host response and microbiome influence risk of preterm birth, early infant microbiome acquisition and neonatal health? What are the mechanisms by which the microbiome exerts effects on the female urogenital tract?
Principal Investigators: Gregory A. Buck, PhD; Kimberly K. Jefferson, PhD Jerome F. Strauss, III, MD, PhD
VCU Center on Health Disparities
Project Principal Investigators: Kimberly K Jefferson, PhD; Timothy P York, PhD